- Posted by DanTomas
Topics discussed: Hives outbreak, Migraine outbreak, Daosin, Cholecalciferol, Menatetrenone
This is an addendum to my guides on treating chronic idiopathic hives and migraines. Part one provides a metabolic protocol, and part two is a psychophysical protocol. Although we are making progress in understanding the root cause of our condition and hopefully taking corrective action, it will likely take months for your body to recover. Those guides are designed for long-term recovery. However it begs the question, what do you do if you have a dinner date and you look like you have been attacked by a swarm of African killer bees? Here we will focus on how to suppress a hives outbreak.
Locking yourself up in your home would be counter productive as it is another potential long-term stressor, exactly what we need to avoid. You can see how we easily end up in a negative feedback loop with stress, leading to hives, leading to further stress. The absolute first step is to relax and take a few deep breaths and make a couscous decision to reduce your anxiety. The crux of the psychosomatic protocol is that our stress response directly impacts our immune system causing systemic histamine overload. This is true for chronic stress and short term panic attacks.
Assuming you have firstly attempted to calm your mind, here are some tools that all sufferers should have on hand for emergencies:
Daosin (Diamine Oxidase Supplementation)
The underproduction of the histamine degrading enzyme DAO is the reason our histamine levels rise beyond our threshold level resulting in a migraine or hives outbreak. This enzyme is mainly produced in the small intestines, liver, and kidneys, and white blood cells. Sciotec have developed the worlds first DAO supplement extracted from porcine kidneys. Supplementing DAO is far superior to antihistamines because you are removing the histamine, whereas antihistamines only relieve the symptoms of histamine. As with all new technology, DAO is relatively expensive. Enzyme and protein manufacture in general is costly due to necessary isolation, extraction and purification. Sciotec are currently recouping R&D under patent and we are still in the early days with respect to cost of production. Expect costs to drop over coming years but for now Sciotec products have limited licences for distribution. Prices are £0.83 – £0.71/pill depending on quantity ordered.
Guidelines are to take one capsule twice per day before meals, but it also makes sense to take a pill according to your DAO levels which you have probably learned to gauge already. For example, if you have a few unnoticeable welts or can feel the onset of a migraine then we can say your DAO is borderline, meaning you could flip into an outbreak after eating almost anything. If you are presently symptom free and you are not planning on going out I would skip a pill. The power of DAO in a pill is that it will give you some freedom back in what foods you eat. Frustratingly a lot of the foods we enjoy happen to be high in histamine; so cheeses, alcohols (especially wines and beers), cured meats etcetera are normally to be avoided. Of special concern for us seeking peak health, high histamine fermented foods happen to the best sources for vitamin K2. An elimination diet is still the best strategy in the early days when your DAO production is at rock bottom however as you recover you will find Daosin will help you to eat, work and socialise as normal. Being able to eat what you want (within reason) will improve your overall mood status which is essential in our long-term psychosomatic protocol.
Topical Cholecalciferol (vitamin D3)
We have discussed the importance of supplementing oral vitamin D3 here. However for suppressing a hives outbreak it would be wise to use a topical vitamin D3 product given that D3 is readily absorbed through the skin and can directly target visible inflammation. It should be noted that vitamin D is unlike any other vitamin in that it is not present in our diet in any meaningful quantity, rather it is produced by our skin in the presence of UVB radiation. Indeed this is why vitamin D3 is the only vitamin that is recommended for breastfed babies that are not getting adequate sun exposure. Ideally our skin will contain the highest concentration of D3 and diffuses inwardly via our bloodstream. When we are in a state of health oral delivery works perfectly well, but when we are suffering skin pathologies then a topical delivery is far more efficient.
D3 is classified as a secosteroid hormone, which is a group of steroids used to provide relief for inflamed areas of the body. Studies have shown it exerts broad anti-inflammatory actions via vitamin-D receptors (VDRs) expressed throughout the immune system. D3 metabolites suppress IgE-induced pro-inflammatory and vasodilatory mediator production (histamine). What this means is that histamine is prevented from being produced in the first place. Vitamin D3 in combination with DAO are the ideal tools to suppress a hives outbreak.
Menatetrenone (Vitamin K2)
K2 is not directly involved in the pathogenesis of an outbreak however we must be aware of K2 levels on a low histamine diet. This is a fascinating vitamin that we are only now beginning to understand, and one which is not discussed enough in the community. It is essential for the function of several proteins, the maintenance of arterial wall structure, osteoarticular system, teeth, and for the regulation of cell growth. There is mounting evidence that K2 deficiency is a common cause in the development of vascular calcification and osteoporosis. A 2005 study found that a combination of vitamins K2, D2, and calcium was shown to decrease fractures by up to 84%. Bone and heart heath is of importance to everybody but especially athletes who place greater stress on their skeletal system, and older people who loose bone density with age. The reason we as sufferers of urticaria and migraines are most at risk is that we eliminate the only foods that contain vitamin K2 in any significant quantity. These are foods such as cheeses, fermented vegetables, and especially natto (a traditional food from Japan made from fermented soybean). The best strategy is to get your DAO levels under control with a low histamine diet and supplement with vitamin K2. When you feel you are completely symptom free you can consider reintroducing theses foods with DAO pills to hand if required.
Key point here. Vitamin K2 exists in two forms, MK4 and MK7. The latter form is produced from fermented soy beans however many people are sensitive to soy and it can therefore increase histamine. MK4 is produced through chemical synthesis, however it is hypoallergenic and it also has the most clinical evidence. It is the ideal form especially for people with immune system disfunction like us.
Although the above tools are excellent for managing a hives outbreak, the risk is that you use them as a crutch. I would recommend maintaining focus on the longterm protocols, they are harder to implement but will provide a real route to recovery. Do not allow a hives outbreak to get you down and know there is light at the end of the tunnel.
If this addendum was useful please like and write back with your experiences. This will help me to update these guides and home-in on the details.